Bioavailability of Xylitol-Containing Products in Saliva
P. MILGROM, C. RIEDY, K.A. LY, M. ROTHEN, G. MUELLER, M. HAGSTROM, L. ZHOU, E. TOLENTINO, and M.C. ROBERTS, University of Washington, Seattle, USA

Objectives: This study examined the presence and time course of xylitol concentrations in saliva delivered via a variety of xylitol-containing products.

Methods: Adults (N=15), using a within-subjects design, received three xylitol-containing products [xylitol pellet gum (2.6 g xylitol), xylitol gummy bears (2.6 g xylitol), and commercially available xylitol stick gum (3.0 g xylitol)]. Subjects consumed one xylitol product per visit with a 7-day interval between each product. A standardized protocol was followed for each product visit. Product order was randomly determined at the initial visit. Saliva samples (0.5 to 1.0 ml) were collected at baseline and 10-12 time points after product consumption initiated (xylitol gums 1, 2, 3, 4, 5, 7, 9, 11, 13, and 15 minutes; xylitol gummy bears after 1st gummy bear, after 2nd gummy bear, 2, 4, 6, 8, 10, 12, 14, and 16 minutes). Concentration of xylitol in treated saliva samples was analyzed using isocratic high-performance liquid chromatography (HPLC) separation of sugars. Area under the curve (AUC) for determining the average xylitol salivary concentration over the total sampling period was calculated for each product.

Results: All xylitol products (pellet and stick gums, gummy bears) had similar time curves with two xylitol concentration peaks during the sampling period. The mean first peak was at 4 minutes [pellet gum (6.8 ng/ml); gummy bears (7.2 ng/ml); and stick gum (6.0 ng/ml)]. The mean second peak was at 13 minutes [pellet gum (4.2 ng/ml); stick gum (3.4 ng/ml)], and at 14 minutes [gummy bears (4.0 ng/ml)]. Total AUC for the products did not differ significantly (pellet gum 34.72, gummy bears 39.74, and stick gum 30.34).

Conclusion: Despite differing modes of delivery, these xylitol-containing products had similar time curves and mean xylitol concentration peaks suggesting that their effects (reduction in bacteria levels or decay) should also be similar.

NIDCR-NIH U54 DE14254

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