|1150 Non-Surgical Treatment of Chronic Periodontitis Using Photoactivated Disinfection|
N. LOEBEL1, R. ANDERSEN1, D. HAMMOND1, S. LEONE2, and V. LEONE2, 1Ondine Biopharma Corporation, Redmond, WA, USA, 2Silver Lake Dental Complex, Everett, WA, USA|
Objectives: The aim of the present study was to compare the safety and effectiveness of scaling and root planning (SRP) alone to that of SRP plus a single photodynamic disinfection (PDD) treatment using a photosensitizer and a diode laser for the non-surgical treatment of chronic periodontitis.
Methods: A randomized single center study was conducted to test the safety and efficacy of photoactivated disinfection in combination with SRP versus SRP alone for 3 months. Endpoints included per subject mean changes in clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) from baseline. Qualifying patients had Ан 6 mm pockets with BOP. There were a total of 33 patients entered into the study with 5 patients treated with photoactivated disinfection alone, 13 patients with SRP alone, and 15 patients with photoactivated disinfection plus SRP. A total of 622 sites were clinically treated. Clinical measurements were taken at baseline, 3 weeks, 6 weeks, and 12 weeks after initial therapy.
Results: All 3 therapies resulted in significant improvements from the baseline in clinical attachment level, probing depth, and bleeding on probing. The mean probing depth reductions at 12 weeks were: PDD = .67mm; SRP = 0.74mm; and SRP + PDD = 1.11mm. The gain in CAL was PDD = 0.14mm, SRP = 0.36mm, and SRP + PDD = 0.86mm. The clinical attachment level improvement was at all time points significantly greater in the PDD plus SRP group than the SRP alone group (p<0.01). There was no difference in the incidence of adverse events among treatment groups.
Conclusions: This data indicates that the combination of SRP and PDD significantly improves the clinical parameters of periodontal disease including an improvement in clinical attachment level and a decrease in pocket depth during the 12 weeks after treatment.
|Seq #142 - Periodontal Therapy and Prevention|
2:00 PM-3:00 PM, Friday, 10 March 2006 Dolphin Hotel Pacific Hall