1729 Maternal Xylitol Consumption to Prevent Mother-Child Transmission of Mutans Streptococci
Y. NAKAI, C. ISHIHARA-SHINGA, M. ISHIHARA-KAJI, K. MORIYA, M. YONEDA, K. YAMANAKA, Y. MORI, Y. JI, and T. SHIMONO, Okayama University, Japan

Objectives: The aim of this study was to evaluate the effect of maternal use of xylitol chewing gum during and after pregnancy on mother-child transmission of mutans streptococci (MS). Methods: After screening, 84 pregnant women with high salivary MS levels were randomly assigned into the xylitol (n=49) and control (n=35) groups. The participants in the xylitol group were instructed to chew one piece of the gum containing 100% xylitol as a sweetener for 5 min at least 4 times a day. Maternal chewing started at their 6th month of pregnancy and terminated 13 months later. The outcome measure was the presence of MS from the children's saliva and plaque at the age of 6, 9, 12 and 18 months assessed by using Dentocult SM (Orion Diagnostica, Espoo, Finland). Results: At 6 months of age, 0% of children in the xylitol group and 5.9% in the control group showed a detectable level of MS. There was no significant difference between them (p=0.165, Fisher's exact test). The children in the xylitol group, however, were significantly less likely to have a detectable MS than in the control group at and after 9 months of age (6.8% vs 37.0%; p=0.003 at 9 months of age, 15.0% vs 76.9%; p<0.001 at 12 months, 42.9% vs 91.7%; p=0.009 at 18 months). Conclusions: The results of this study suggest that maternal use of xylitol chewing gum during and after pregnancy can effectively reduce the probability of mother-child transmission of MS.

Seq #143 - Epidemiology/Clinical Studies
11:00 AM-12:00 PM, Friday, 30 June 2006 Brisbane Convention & Exhibition Centre Exhibit Hall 1

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