1090 C-Reactive Protein: A Systemic Connection between Periodontal and Coronary Disease
J. WESSEL, University of Michigan, School of Dentistry, Ann Arbor, USA, and G. TAYLOR, University of Michigan, School of Dentistry, Ann Arbor, USA

Objectives: This study evaluated the relationship between periodontal disease, coronary disease and C-reactive protein. Methods: We analyzed data from U.S adults who participated in the Third National Health and Nutrition Examination Survey. C-reactive protein levels (CRP) were measured in fasting peripheral blood. Severe periodontal disease (sPD) was defined as at least one site with >= 6 millimeters attachment loss and gingival bleeding. Coronary disease was defined as self-reported myocardial infarction (MI), electrocardiogram defined MI, or presence of angina. Results: Logistic regression modelling showed that individuals with both coronary disease and sPD or only sPD or coronary disease are significantly more likely to have higher CRP than individuals with neither disease (odds ratios: 2.38, 1.93, 1.87, respectively). Conclusions: The results suggest both sPD and coronary disease are associated with higher CRP, and there may be a gradient in the association between higher CRP and presence of none, one or both diseases.

Seq #128 - Systemic States, Risks, and Influences
2:00 PM-4:00 PM, Thursday, 10 March 2005 Baltimore Convention Center Exhibit Hall E-F

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