3662 GC-MS Analysis and Antibacterial Activity of Artemisia iwayomogi Essential Oil
Y.-O. YOU, H.H. YU, S.H. HAN, S.J. SEO, Y.H. KIM, S.L. JEONG, and K.J. KIM, Wonkwang University, Iksan, Chonbuk, South Korea

Objective: Essential oils have been proposed as antibacterial agents and mouthrinse solutions. Artemisia iwayomogi have been used in Oriental traditional medicine to treat various infections and inflammations. The antibacterial activity of the essential oil from A. iwayomogi and its chemical composition were investigated in this study. Methods: Analysis of the oil by GC and GC-MS has revealed 75 compounds. Antibacterial activity was investigated against the four strains of oral pathogens, including Streptococcus mutans, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. The minimum inhibitory concentration (MIC) values were determined using MH broth-dilution method. Result: The monoterpenes camphor (19.31 %), 1,8-cineole (19.25 %), borneol (18.96 %), camphene (4.64 %) and the sesquiterpenes beta-caryophyllene (3.46 %) were the major components. The oil (MIC in the range of 0.4-1.6 mg/ml) exhibited antibacterial activity. The antibacterial activity of standard terpenoids, camphor, 1,8-cineole, borneol, camphene, and beta-caryophyllene, which were found to be the major compounds of the essential oil from A. iwayomogi was also tested. These major components of the oil showed the antibacterial activity against oral bacteria. Conclusion: These results suggest that essential oil of A. iwayomogi may have the antibacterial activity against oral bacteria and it may be attributed to its content of the terpenoids, camphor, 1,8-cineole, borneol, camphene, and beta-caryophyllene. This paper was supported by a grant No. R01-2001-000-00133-0 from Korea Science & Engineering Foundation and research fund.

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