1166 PepGen P-15 Peptide-enhanced Grafts for Sinus Augmentation in Humans
R.A. YUKNA, S. VASTARDIS, and E.T. MAYER, Louisiana State University, New Orleans, USA

Objective: Placement of dental implants in the posterior maxilla is often compromised by the presence of an enlarged maxillary sinus. Many graft materials, alone or in combination, have been used to augment the alveolar bone height and width in the sinus regions. Most of these have resulted in satisfactory amounts of new bone (30-40%) formation after 6-12 months.

Methods: A new peptide-enhanced graft material (PepGen P-15) in particulate and/or flowable form was used to graft maxillary sinuses in 16 patients prior to dental implant placement. Trephine biopsies taken at implant placement from 4 - 18 months after grafting were processed for histologic evaluation of new bone formation.

Results: Histometric evaluation demonstrated percentages of new bone formation ranging from 40-70% (resulting in Type 2 bone), even at earlier time periods (4-6 months).

Conclusion: These improved and more rapid new bone formation results suggest that PepGen P-15 provides an important advance in graft material for sinus augmentation.

Supported by Dentsply Friadent CeraMed and the Louisiana Periodontics Support Fund

Seq #123 - GTR and New Bone Grafting Materials
3:45 PM-5:00 PM, Thursday, 26 June 2003 Svenska Massan Exhibition Hall B

Back to the Periodontal Research - Therapy Program
Back to the 81st General Session of the International Association for Dental Research (June 25-28, 2003)

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