0632 Effect of a Sodium Lauryl Sulphate-free Dentifrice w/wo Betaine on Recurrent Oral Ulcerations
E. SÖDERLING, I. RANTANEN, and J. TENOVUO, Institute of Dentistry, University of Turku, Finland

Objective: The aim of this study was to compare the effects of mildly flavoured sodium lauryl sulphate (SLS)-containing and detergent-free toothpastes with and without betaine on patients with recurrent oral ulcerations (ROU). Methods: Twelve healthy subjects (mean age 32.8 years, age range 10-57 years) suffering from ROU took part in randomised, controlled study. The three toothpastes with (i) 4% betaine (BET), (ii) 1% SLS and 4% BET and (iii) 1% SLS were used 2 min twice a day for 5 weeks, 1.5 g paste at a time. The test periods were separated by 2-wk washout periods when reference toothpaste containing neither SLS nor BET was used. The appointments were set at the beginning of the trial and before and after the use of the toothpastes. At each appointment the number and size of ulcers was evaluated and the subjects were interviewed for subjective discomfort associated with the ulcers and preference of paste. Results: At the baseline of the study the subjects reported occurrence of ulcers at least once a month (mean 3.2 ±2.4 per month); three subjects suffered constantly from several ulcers. No significant changes in the occurrence, size or duration of oral ulcers took place during the study and no differences were seen in these variables when the toothpastes were compared. Also no significant changes in oral discomfort were detected during the study. The patients did not prefer any of the pastes over the others. Conclusion: The SLS and betaine when used in a mildly flavoured toothpaste formula had no significant effect on the ulcer pattern or the oral discomfort of the ROU patients. Supported by National Technology Agency, Finland.

Seq #71 - Oral Tissues, Pharmacology
11:00 AM-12:15 PM, Thursday, 26 June 2003 Svenska Massan Exhibition Hall B

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