|3546 Salivary fluoride levels following fluoride varnish or fluoride rinse|
W.S. EAKLE, J.A. WEINTRAUB, S.A. GANSKY, and J.D.B. FEATHERSTONE, University of California, San Francisco, USA|
Elevated fluoride (F) in whole saliva (>0.04 ppm) is related to lower risk of caries progression. Objective: to compare F release into whole saliva over time by F varnish (Duraflor, Pharmascience, 5% NaF) versus F rinse (ACT, Johnson & Johnson, 0.05% NaF).
Methods: This two-period, two-treatment cross-over study randomly assigned 16 adults to 1 of 2 sequences: F rinse, then F varnish or the reverse order. A two-week washout period was observed between treatments. Rinsing was with 10 ml of F rinse for 30 s. Varnish was applied once to facial and lingual surfaces of 20 teeth. Stimulated whole saliva was collected at baseline, then at 5, 10, 15, 60 min, and 2, 4, 8, 12, 24, 32, 48, 56, 72, 80, 96, 104 h after treatment. Taves (1968) microdiffusion method analyzed salivary F content.
Results: Salivary F was at mean peak levels (± standard error) for rinse (3.2 ± 0.8 ppm) and varnish (24.5 ± 4.9 ppm) 5 minutes after application. F for the rinse returned to baseline in <4 h and for the varnish in <24 h. Within-person log10 (maximum F) (p<0.01) was significantly greater for varnish than rinse using linear models. No carry-over effects (p=0.76) were observed. No treatment difference in F concentration between baseline and 104 h (p=0.17) was seen.
Conclusions: F varnish treatment significantly (p<0.01) increased whole salivary F above that with F rinse and for a longer duration. Support: A.R. Medicom, Inc.
|Seq #321 - Fluoride, Dentifrices, Mouthrinses|
11:00 AM-12:15 PM, Saturday, 9 March 2002 San Diego Convention Center Exhibit Hall C