1736 Cartilage matrix gene expression in rabbit TMJ bilaminar zone
Z. GU, Zhejiang University, Hangzhou, Zhejiang Province, China, J. FENG, Zhejiang University, Hangzhou, China, T. SHIBATA, Yamagata University, Japan, Z. ZHANG, Piking University, Beijing, China, and J. HU, Zhejiang University, hangzhou, China

Objectives: In order to study the pathological changes and cartilage matrix gene expression in rabbit TMJ bilaminar zone (BZ) following disc displacement. Methods: Forty adult Japanese white rabbits were studied. The right joints of 28 among the 40 rabbits were subjected to surgical operation of disc displacement. Four rabbits in the surgical group were killed in 4 days, 1, 2, 4, 6, 8 and 12 weeks respectively after operation. Their TMJs were studied by histochemistry and in situ hybridization. The aggrecan and type Άς collagen mRNA expression was researched in the BZ following disc displacement. Results: In the experimental animals, the collagen fibers in BZ became densely, especially near the posterior band of the disc. Chondrocytes were found not only in the discs, but also in the BZs. There were two types of chondrocytes in the BZs. One was located among the collagen fibers, other was close to the surface of BZs. Sometimes the cartilage formation were seen in BZ and disc. The type Άς collagen mRNA expression was detected first in BZ in four days post-operative animal, and the gene expression seemed to be stronger and stronger after then. The aggrecan expression decreased at first, then increased gradually in 4 weeks post-operation. Conclusions: Some cells in the BZs changed their gene expression and the BZs became a fibrocartilage after disc displacement. In the situation, the BZ may work as a disc .

Seq #166 - TMJ - Structure and Function I
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