| 0322 Preterm Birth with Chorioamnionitis and Antibody Response against Porphyromonas gingivalis | ||
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N. SUGITA1, Y. SHIMADA2, T. KOBAYASHI2, Y. ABIKO3, and H. YOSHIE4, 1Niigata University, School of Dentistry, Japan, 2Niigata University, Japan, 3Nihon University, Matsudo Chiba, Japan, 4Niigata University, Graduate School of Medical and Dental Sciences, Japan Objectives: Although recent studies suggest the association between maternal periodontal disease and the risk of preterm birth, conclusions are not consistent between authors. Madianos et al. suggested that maternal periodontal infection in the absence of IgG response against periodontopathic bacteria is associated with systemic dissemination of these organisms and the risk of prematurity. Specific IgG antibody against a 40-kDa outer membrane protein of Porphyromonas gingivalis (P.g. 40-kDa OMP) has bactericidal activity and increase in serum from patients with chronic periodontitis. In this study, we assayed the levels of anti- P.g. 40-kDa OMP IgG1 and as inflammatory markers; TNF-alpha and CRP in maternal serum obtained during early stage of pregnancy, and analyzed the relationship between these levels and the risk of preterm birth and the presence of chorioamnionitis. Methods: Serum samples were obtained before 15 weeks of pregnancy from women referred to the Department of Gynecology of Niigata University Medical and Dental Hospital (term birth: 98, preterm birth: 65). The levels of anti- P.g. 40-kDa OMP IgG1 and TNF-alpha were determined by ELISA and CRP levels by Latex Turbidometric Immunoassay. Presence and severity of chorioamnionitis were histologically determined. Multiple pregnancies, incompetent cervix, congenital abnormalities of uterus were excluded. Results: Anti- P.g. 40-kDa OMP IgG1 levels were significantly lower in serum from preterm compared to term. Lower level of anti- P.g. 40-kDa OMP IgG1 was definite for preterm with chorioamnionitis (P<0.001). Significantly higher TNF-alpha level was observed in preterm compared to term case even in the serum from first trimester of pregnancy. Preterm case with chorioamnionitis also demonstrated significantly higher level of serum CRP levels. Conclusions: In the early stage of pregnancy, the levels of serum anti- P.g. 40-kDa OMP IgG1 were lower and the inflammatory markers were higher in women who had subsequent preterm labor compared to women with term labor. | ||
| Seq #36 - Periodontal Research: Pathogenesis 4:00 PM-5:30 PM, Friday, September 28, 2007 Ioannis Vellidis Congress Centre Hall "Ellopia 2A" | ||
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