| 0243 Bone Regeneration Using beta-Tricalcium Phosphate in a Calcium Sulfate Matrix | ||
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L. PODAROPOULOS1, A. VEIS2, S. PAPADIMITRIOU3, C. ALEXANDRIDIS1, D. KALYVAS1, and D. PRINTZA2, 1University of Athens (EKPA), Greece, 2University of Thessaloniki, Greece, 3Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece Objectives: The aim of the study was the histomorphometric comparison of the osteogenic potential of beta-tricalcium phosphate alone or in a calcium sulfate matrix. Materials and methods: Three round defects, 10 (diameter) x 5 (depth) mm, were created on each iliac crest of 4 dogs. The defects were divided in 3 groups. Ten defects were filled with beta-tricalcium phosphate (beta-TCP) in a calcium sulfate (CS) matrix (Fortoss Vital®) – (group A), 10 defects were filled with beta-tricalcium phosphate alone (Fortoss Resorb®) – (group B) and 4 defects were left ungrafted to heal spontaneously – (group C). All defects were left to heal for 4 months without the use of a barrier membrane. Histologic evaluation and morphometric analysis of undecalcified slides was performed using the areas of regenerated bone and graft remnants. Results: All sites exhibited uneventful healing. In group A sites (beta-TCP/CS) complete bone formation was observed in all specimens, graft granules dominated the area and a thin bridge of cortical bone was covering the defect. Group B (beta-TCP) defects were partially filled with new bone, the graft particles still dominated the area, while the outer cortex was not restored. In the ungrafted sites (group C) incomplete new bone formation was observed. The outer dense cortical layer was restored in a lower level, near the base of the defect. The statistical analysis revealed that the mean percentage of new bone regeneration in group A was higher than in group B (49.12% and 40.53% respectively). Statistically significant difference existed between the two groups. The beta-TCP/CS group exhibited significantly higher new bone regeneration according to a marginal probability value (P=0.042<0.05). Conclusion: The use of beta-TCP in a CS matrix produced significantly more vital new bone fill and preserved bone dimensions than did the use of beta-TCP alone. | ||
| Seq #27 - Implantology 11:30 AM-1:30 PM, Friday, September 28, 2007 Ioannis Vellidis Congress Centre Hall 3 "Alexandros" | ||
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