Objectives: This retrospective study evaluated the success of conscious sedation with different kinds of routes of administration and drugs in pediatric dental patients. Methods: In a two-year retrospective study, 363 records of conscious sedation performed in 242 healthy children aged 30 to 82 months were examined. The records were divided into 5 groups according to drug, route and dosage selection. Group 1: All subjects received a standard oral dose of 0.75 mg/kg of midazolam (5mg/5ml) with %50-50 nitrous oxide / oxygen (N2O/O2). Group 2: received a standard oral dose of 0.50 mg/kg of midazolam (5mg/5ml) with %50-50 N2O/O2. Group 3: received a standard intranasal dose of 0.20 mg/kg of midazolam (40mg/ml) with %50-50 N2O/O2. Group 4: received a standard oral dose of 10 mg/year Hydroxyzine with %50-50 N2O/O2. Group 5: only inhalation sedation with %50-50 N2O/O2. Variables were examined for effect on outcome of sedation and rated as: 1- successful : if treatment plans were successfully completed 2- failure : If the cases were aborted because of disruptive behavior 3- not accepted: If the patient did not accept the route of administration or drug Also all types of treatment were recorded. Results: The highest success rate was found in Group 3 (84.48%) and the highest failure rate was found in Group 5 (23.97%). Total success rate was 70.80% in all groups. Conclusion: This retrospective study showed that conscious sedation is a successful adjunct to the clinical management of pediatric dental patients.

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