Objectives: Chlorhexidine digluconate (CHX) is one of the effective antibacterial agents and it has been widely used during past years in dental applications. The objective of this pilot study was to determine the release of CHX from laced unidirectional E-glass fibre reinforced provisional fixed partial denture polymer. Materials and Methods: Test specimens were made of autopolymerizing provisional FPD resin of poly (ethylmethacrylate) (PEMA) powder and (bytyl methacrylate) (BMA) monomer liquid and glass fibre reinforcements containing E-glass fibres and porous polymethyl(methacrylate) (PMMA) preimpregnation polymer. The fibre reinforcement was immersed with chlorhexidine digluconate – water solution for one minute. The fibre reinforcements were then dehydrated in desiccators for one week before using them in the test specimens fabrication. The bar shaped test specimens (3.3x10x65mm3) were fabricated according to ISO 1567. The test specimens were stored in the contact with 40 ml of de-ionized Milli-Q water at +37°C (in closed Falcon flasks) for the following time points: 0, 1, 3, 7, 10, 14, 21, and 180 days. The released chlorhexidine digluconate (CHX) was measured using high performance liquid chromatography (HPLC). Results: The CHX was leached out from the test specimens within the first three weeks (from 13 ppm to 36 ppm). After 21 days incubation in water, the extracted CHX concentration was ca. 90 % from the total CHX concentration after 180 days' incubation. Conclusion: Within the limitations of the study, the following conclusion can be drawn: From the specimens of CHX-E-glass fiber-reinforced FPD, the CHX releases most within the first seven days and even significantly in 21 days, where after the releasing did not increase a lot.

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