Objectives: FcγR gene polymorphisms may play a role in the susceptibility and severity of periodontitis. FcγR polymorphisms have been associated with periodontitis in Caucasians and Japanese. In a longitudinal epidemiological study (15 year follow-up), among Indonesians who were deprived of dental care, it was determined who showed severe periodontitis during follow-up. The purpose of the present study was to investigate FcγR gene polymorphisms in relation to severe periodontitis in this Indonesian cohort.

Methods: 127 Indonesians (67 male, 60 female) participated. Venous blood was obtained and genomic DNA was extracted. Determination of polymorphisms for the FcγRIIa (H or R131), FcγRIIIa (V or F 158), and FcγRIIIb (NA1 or NA2) genes were performed.

Results: The subjects had a mean age of 37 years. Mean attachment loss (AL) was 2.0 mm. The subjects had a mean of 1.4 ± 3.9 teeth with pocket depths (PD) ³5 mm in combination with AL ³6 mm. 26 subjects (21 %) were classified with severe periodontitis (³2 sites with PD ³5 mm in combination with AL ³6 mm), while the remainder of subjects were diagnosed with mild periodontitis. The FcγRIIa-R131 carriage was prevalent in severe patients in 69 % versus 54 % in mild periodontitis (P= 0.191). Carriage of FcγRIIIa-V158 was in the majority of subjects (85 % in severe group versus 79 % in mild group, P= 0.728). The FcγRIIIa-NA2 allele was present in about half of the subjects, and not different between severe and mild periodontitis (50 % and 56 % respectively, P= 0.660). Further, mean AL or the mean number of sites with PD ³5 mm in combination with AL ³6 mm were not different per genotype for each of the FcγRIIa, FcγRIIIa and FcγRIIIb genes.

Conclusion: FcγR gene polymorphisms were not associated with severity of periodontal disease progression in an Indonesian cohort.

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