| 0197 Evaluation of Polylactide-Polyglycolide Fisiograft® in Treatment of Deep Intrabony Defects | ||
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A. BACILA, Periodontal Clinic Dr.Stratul, Timisoara, Romania, S.-I. STRATUL, Victor Babes University of Medicine and Pharmacy Timisoara, Romania, and A. SCULEAN, Johannes Gutenberg-University Mainz, Germany A polylactide-polyglycolide copolymer (Fisiograft®, Ghimas S.p.A., Italy) was recently used to treat closed bone defects and for sinus floor augmentations. The material is manufactured as gel, granules or sponge, displays a good handling during the surgery; degradation occurs through “bulk erosion” by hydrolysis. Objectives: to compare clinically the treatment of deep intrabony defects with the combination of flap surgery (FS)+ Fisiograft® to the FS alone. Methods:13 patients with chronic periodontitis, displaying a total of 24 deep intrabony defects, were randomly treated either with FS + Fisiograft® (test) or with FS(control). Soft tissue measurements were made at baseline and six months following the surgery. The Wilcoxon paired-samples test was used to statistically evaluate the changes from baseline to six months;the Mann-Whitney U independent-samples test was used for comparison between the groups. Results:No differences in any of the investigated parameters were observed at baseline between groups. Healing occurred uneventful in all patients. At six months after therapy, the test group showed a reduction in mean probing depth (PD) from 7.92 ± 1.88 mm to 3.83 ± 1.27 (p=0.002) and a change in mean clinical attachment level (CAL) from 8.58 ± 1.78 mm to 5.50±1.78 (p=0.003). In the control group, the mean PD was reduced from 7.08 ± 1.08 mm to 4.42 ± 1.44 (p=0.002) and the mean CAL changed from 8.00 ± 1.28 mm to 7.00 ± 2.13 (ns). The test treatment resulted in statistically higher PD reductions (p=0.024) and CAL gains (p=0.02) than the control group. In both groups, a minute or no radiographic defect fill was observed at six months after treatment. Conclusions:1) at six months after the surgery both therapies resulted in PD reductions and CAL gains, and 2) treatment with access flap + Fisiograft® resulted in significantly higher CAL gains and PD reductions than treatment with FS alone.
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| Seq #20 - Periodontal Research - Therapy 9:00 AM-11:00 AM, Friday, 27 August 2004 Crowne Plaza Hotel SEDIR I | ||
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