| 0445 Atherosclerosis in Periodontitis | ||
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E. LEIVADAROS1, U. VAN DER VELDEN1, S. BIZZARRO1, A.-M. TEN HEGGELER1, V. GERDES2, F.J. HOEK2, T.O.M. NAGY3, J. SCHOLMA3, S.J.L. BAKKER4, R.O.B. GANS4, H. TEN CATE5, and B.G. LOOS1, 1 ACTA, Amsterdam, Netherlands, 2 Academic Medical Center, Amsterdam, Netherlands, 3 Slotervaart Ziekenhuis, Amsterdam, Netherlands, 4 Academic Hospital Groningen, Netherlands, 5 Academic Hospital Maastricht, Netherlands Objectives: Epidemiological studies have linked periodontitis with cardiovascular diseases. The current pilot study explored arterial wall thickness of carotid arteries and plasma molecules associated with atherosclerosis, in subjects with and without periodontitis. Methods: Subjects > 45 years with moderate (N=34) or severe periodontitis (N=15) or healthy (N=14) were recruited. Intima Media Thickness (IMT) of the common carotid arteries (CCA), internal carotid arteries (ICA) and bifurcations of carotid arteries (BCA), was estimated bilaterally using B-mode ultrasound. An overall IMT was calculated as the mean of these 6 measurements. CRP, fibrinogen and von Willebrand factor (vWf) were measured in plasma as indicators of systemic inflammation and atherosclerotic disease. Microalbuminuria was determined as marker of endothelial cell dysfunction. Results: IMT for CCA were 0.64, 0.68 and 0.69 mm for control, moderate and severe periodontitis respectively (not significant). Also IMT for BCA were not different between groups. IMT of ICA was largest for severe periodontitis (0.81 mm); corresponding values for controls and moderate periodontitis were 0.58 and 0.55 mm respectively (P=0.023). Severe periodontitis patients had an overall IMT of 0.76 mm, while moderate periodontitis patients and controls had lower values (0.64 and 0.65 mm respectively; P=0.153). After adjusting for potential confounding factors, the increased IMT for ICA in severe periodontitis was also significant (Padj=0.040). CRP (P=0.020, Padj=0.050) and vWf (P=0.019, Padj=0.013) were higher in periodontitis than controls; microalbuminuria was not different between groups. Power calculations suggest that a 4-fold expansion of the severe patient and control groups will result in a high chance (power level 80%) that a clinically significant association between the overall IMT and periodontitis will be observed. Conclusions: The present pilot study indicates that a full study investigating the relationship between periodontitis and atherosclerosis is warranted. The authors thank A.A.M. Hart kindly for statistical advice and Philips BV for partial support. | ||
| Seq #41 - Periodontal Research - Diagnosis/ Epidemiology 9:00 AM-11:00 AM, Saturday, 28 August 2004 Crowne Plaza Hotel SEDIR I | ||
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