Abstract: Objectives:A preliminary study to standardize the effects and results of intralesionel methylprednisolone acetate application in the mucosal destruction seen in autoimmune disesaes of the oral cavity. Method: 24 male Sprague- Dawley albino rats were anesthetised with i.p. ketamin (100 mg/kg) and standart wounds performed on by using hemostatic clamps in both buccal mucosa. 0.01cc. methylprednisolane acetate microenjection was applied to the right buccal wound. Only neddle insertion by the same syringe was applied to the left wound as the control side. The wounds on each side were totally excised on 1st, 3rd, 5th days and histopathological comparison under light microscope was performed. Results: Significant differences were observed (p<0.05) in both groups in epithelial regeneration and lenfocyte, plasma cells, macrophage and exudate accumulation and abscess, oedema, fibrosis and necrosis formation. However no significant differences were observed in endothelium proliferation, hyperemia and PNL infiltration in both sides (p<0.05). Conclusion: Wound healing and epithelial regeneration was better in the study group on the 3rd day compared with the control group. On the 5th day acute infection symptoms and increase in PNL accumulation was observed in both groups. This may be due to the decrease in the depo effect of methylprednisolone acetate.

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