| Thursday, July 3, 2008 | ||||||||
| 12:15 PM-1:30 PM Metro Toronto Convention Centre Level 600 Foyer (Reg Area), Lunch and Learning | ||||||||
| Pyrophosphate and SIBLING Proteins Regulating Mineralization | ||||||||
Sponsored by: Mineralized Tissue | ||||||||
| Description: Molecular determinants of skeletal, dental and pathologic mineralization include inhibitory SIBLING proteins, and the small-molecule inhibitor pyrophosphate. These mineralization inhibitors are substrates for tissue-nonspecific alkaline phosphatase, an enzyme that degrades pyrophosphate and dephosphorylates SIBLING proteins, thus modifying their mineral-inhibiting activity. The influence of these factors on mineralization will be discussed. | ||||||||
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