Quercetin is a flavonol available commonly in onion and apple is also a phytoestrogen. Objective: To compare the amount of new bone produced by quercetin in collagen matrix (carrier) to that produced by the collagen matrix alone. Methods: Eighteen bone defects, 5mm „e 10 mm were created in the parietal bone of 9 New Zealand White rabbits. In the experimental group, 6 defects were grafted with quercetin solution mixed with collagen matrix. In the control groups, 6 defects were grafted with collagen matrix alone (active control) and 6 were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis. Results: A total of 556% more new bone was present in defects grafted with quercetin in collagen matrix than those grafted with the collagen matrix alone. No bone was formed in the passive control group. Conclusions: Quercetin in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting or for bone induction.

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