Objectives: In the early 1980, HA and ß;-TCP became available as bone substitute materials for dental and medical applications. The concept of mixture with varying HA/ß;-TCP (BCP) demonstrated the bioactivity of these ceramics. Subsequently, focussed studies on BCP led to the significant increase in manufacture and use of commercial BCP as bone substitute for dental and orthopaedic applications. However scare human clinical studies for bone reconstruction to support further dental implantation have been published. Methods: The micro macroporous biphasic calcium phosphate (4Bone ™ MIS Israel) is an intimate mixture of HA and TCP with a ratio of 60/40. The total porosity is 70% constituted of 30 % micropores and 70% macropores. After human dental extraction, granules were implanted into the alveolar cavity. After 6 months, dental implantation (Seven™, MIS) was performed and the bone was processed for micro CT, SEM and histology. Results: Radiograph revealed newly formed bone with higher density, traducing residual bioceramics. During drilling, bone density was high without interference with residual granules. Micro CT demonstrates 3D bone ingrowth. Over 50% granules resorption was observed. In SEM and light microscopy, organized and well mineralized bone ingrowth is observed. The residual granules look different in density and structure than granules before implantation confirming previous pre-clinical study of physico-chemical transformation by dissolution precipitation at a microscale level. Bone ingrowth at the expense of Micro Macroporous Conclusion: Biphasic Calcium Phosphate after human implantation at 6 months was confirmed in micro CT, SEM and light microscopy.

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