| 1202 Candida Species in Primary Sjogren's Syndome | ||
|
P.J. HUGHES, K. PATEL, N. RHODUS, C. MEYER, A. LEIRAN, D. PATEL, and K. MOSER, University of Minnesota, Minneapolis, USA Objectives: To determine the candidal species present in primary Sjogren's syndrome, and to correlate findings based on unstimulated salivary flow rates. Our hypothesis is that the incidence of the presence of candida will be increased in primary Sjogren's syndrome as unstimulated salivary flow rates decrease. Also, the authors hypothesize that the species of candida will differ as unstimulated salivary flow rates differ. Methods: Saliva (unstimulated and saline rinse) was collected from 86 Sjogren's syndrome patients. 100uL of the saline rinse was plated on a chormoagar plate (Fisher Scientific) and incubated at 37°C overnight. The chromoagar plate tested the presence of fifteen different Candida species. The colors observed on the plates were correlated to the species present according to the manufacture's recommendations. Results: The number of patients with primary Sjogren's syndrome included in the study was 86. The number of patients that grew candida was 58 (67.5%). Six out of fifteen species tested were identified. The most common species identified was C. albicans (n=57) other species identified included C. glabrata (n=18), C. famata (n=6), C. tropicalis (n=3), C. krusei (n=1),and C. kefyr (n=1). Mean unstimulated salivary flow rates in patients without candida was 2.85(SD=3.21) whereas mean unstimulated salivary flow rates in patients with candida was 0.91(SD=1.51). Mean comparison test (t-test) was used to correlate the presence of candida with decreased unstimulated salivary flow rates and was found to be significant (p-value=0.0002). Conclusions: Decreased unstimulated salivary flow rate significantly correlates with the presence of oral Candida. Six different species of Candida were identified in patients with primary Sjogren's syndrome. Thus far, there is not sufficient data to suggest a relationship between unstimulated salivary flow rates and types of Candida. NIH #RO1AR050782 Biomarkers in Primary Sjogren's Syndrome (BioSIPS) | ||
| Seq #129 - Clinical Diseases and Pathogenesis 3:30 PM-4:45 PM, Thursday, March 22, 2007 Ernest N. Morial Convention Center Exhibit Hall I2-J | ||
|
Back to the Oral Medicine & Pathology Program
| ||