| 1207 Cankermelts Patches Reduce Pain and Speed Resolution of Aphthous Ulcers | ||
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M.D. MARTIN, University of Washington, Seattle, USA, J.A. BURGESS, American Academy of Oral Medicine, Seattle, WA, USA, and J. HALEY, Orahealth Corporation, Bellevue, WA, USA Objectives: Recurrent aphthous ulcers (RAU) are a chronic, painful oral condition treated primarily with OTC medications. This study examined pain levels and ulcer size in a treatment group (TG) treated with a dissolving oral patch (Cankermelts) with an herbal anti-inflammatory, glycyrrhiza (licorice) extract (GX) (N=23) and a no treatment control group (NT) that had similar examination protocols but agreed to leave their canker sores untreated (N=23). Methods: Adult subjects with a new occurrence of RAU were evaluated on days 1, 3, 4, and 8 of an RAU episode. The treatment group was instructed to use the patches 16 hours per day but not while sleeping and to keep usage logs. Subjects' pain both unstimulated and stimulated (with saturated saline swab) were noted at each visit. Ulcers were photographed at each visit, and ulcer size was calculated from photographs by a single examiner. Results: At baseline, mean ulcer size was not significantly different between groups (TG=3.1mm2, NT=2.3mm2 ) although the size was somewhat greater in the treatment group, but by day 8, ulcer size was significantly smaller in the TG than in the NT subjects (TG=0.31mm2, 2.6mm2, p<.001). Unstimulated and stimulated pain scores were not significantly different between groups at baseline, but by day 4, both unstimulated and stimulated pain levels in the treated group were significantly lower in the treatment group than in the untreated group (unstimulated: p<.001, stimulated: p<.01), and this difference persisted through day 8 (unstimulated: p=.01, stimulated: p<.01). Examination of the usage logs revealed mean usage of 8.4 (s.d.=3.4) hours per day. Conclusions: The dissolving oral patch with glycyrrhiza extract significantly speeded resolution (decreased ulcer size) of the RAU, and significantly lowered both passive and stimulated (to simulate the effect of foods) pain levels in the treatment group compared to no-treatment controls. Funding: NIH–NIDCR 1-R41-DE015740-01, and Orahealth. | ||
| Seq #129 - Clinical Diseases and Pathogenesis 3:30 PM-4:45 PM, Thursday, March 22, 2007 Ernest N. Morial Convention Center Exhibit Hall I2-J | ||
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