| 2756 Associations of Bone Measures at Age 11 with Fluoride Intake | ||
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S.M. LEVY, J.M. EICHENBERGER GILMORE, J.J. WARREN, T.A. MARSHALL, E. LETUCHY, B. BROFFITT, J. TORNER, T.L. BURNS, K. JANZ, and M. WILLING, University of Iowa, Iowa City, USA Relationships between fluoride intake and bone health continue to be of interest, as the few previous studies show conflicting results. Objectives: The purpose of this report is to present data concerning associations of fluoride intake with bone measures at age 11. Methods: Subjects have been participating in the ongoing Iowa Bone Development/Iowa Fluoride Study. Their mothers were recruited immediately postpartum 1992-95 from eight Iowa hospitals, and detailed fluoride questionnaires were sent every 1.5-6 months thereafter. From these, combined fluoride intake (n=204, 45% boys) from water (home, childcare, filtered, bottled), other beverages, selected foods, dietary fluoride supplements, and dentifrice was estimated at individual points and cumulatively. Subjects received densitometry (DXA) scans of hip, lumbar spine and whole body (Hologic QDR-4500). DXA results (bone mineral content – BMC; bone mineral density – BMD) were related to fluoride intake in bivariate and multivariable analyses. Results: Mean age for the sample was 11.2 (SD=0.31) years. The mean fluoride intake estimated by AUC was 0.67 mg (0.27) per day (range, 0.20-1.63) for the period birth to 102 months. Correlations between fluoride intake and DXA bone measures at all sites ranged from 0.14–0.21 (p<0.05) for all subjects, 0.24–0.31 (p<0.03) for boys and 0.10–0.17 (p>0.08) for girls. In gender-stratified, and body size- and Tanner Stage-adjusted analyses, positive associations persisted for boys, but not girls. Conclusions: Longitudinal fluoride intake is associated with increased BMC and BMD for boys, but the relationship is less consistent for girls. At 11 years of age, girls exhibit more advanced physical development than boys; therefore, hormonal and growth differences may influence DXA results. Future research is required to determine gender- and age-specific effects of fluoride intake on bone development. Supported by NIH grants R01-DE09551, R01-DE12101, and M01-RR00059. | ||
| Seq #285 - Epidemiology 10:45 AM-12:00 PM, Saturday, March 24, 2007 Ernest N. Morial Convention Center Exhibit Hall I2-J | ||
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