Objectives: In-vitro simulations were used to develop dental materials, but no correlation between simulation and in-vivo behaviour is available. The aim of this study was to compare the in-vivo behaviour with the in-vitro simulation of fixed partial dentures (FPDs).

Methods: 20 FPDs of a fibre-reinforced composite (FRC) system, a lithiumdisilicat ceramic and a zirconia-ceramic system were fabricated according to the manufacturer's instructions and cemented on human molars. The FPDs were artificially aged in an oral environment (TCML1: 18000x5°/55°C, H₂0, 2min. each cycle, 3.6*10⁶x50N; artificial periodontium, human antagonists) and the failure rates were compared to available clinically data (Medline). The simulation parameters were adapted accordingly for achieving a relative correlation between in-vivo behaviour and in-vitro simulation. The simulation was repeated with the revised parameters (TCML2). After simulation all remaining FPDs were loaded to fracture (Zwick 1446, Zwick, G, v=1mm/min). Statistical analysis: Mann-Whitney-U test and Kaplan- Meier (α=0.05).

Results:

	FRC	Zirconia-ceramic	Lithidisilicate ceramic
Fracture resistance [N] after TCML1	689 (580/780)	1212 (1014/1521)	403 (278/453)
Fracture resistance [N] after TCML2	542 (425/591)	916 (843/1407)	426 (297/559)

Conclusions: Established simulation parameters may not be used for artificial aging of different types of FPDs. Within the limitations of this study, a comparable relative failure rate between in-vivo and in-vitro could be achieved by adapting simulation parameters.

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