| 2143 Oral precancer: Objective and Subjective Measures of Nutritional Status | ||
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O. HAMADAH, P. THOMSON, and M. GOODSON, University of Newcastle Upon Tyne, United Kingdom Background: Evidence supports a role for nutrition in the aetiology and management of oral precancer. Observational epidemiologic studies indicate that poor nutrition is associated with an increased risk of oral precancer. Objective: To assess the value of reported fruit and vegetable intake and nutritional markers [albumin and total lymphocyte count (TLC)] as predictors of severity and outcome in oral dysplasia. Methods: 48 patients undergoing laser resection of dysplastic oral lesions were recruited into the study. Informed consent was obtained and blood samples analysed for full blood count and serum albumin. TLC as an objective marker of nutritional status was subsequently calculated. Patients were grouped using TLC and albumin as well or malnourished using standard criteria. Reported fruit and vegetable intake at presentation was recorded by questionnaire and individuals were assessed for recurrence at two years following laser resection. Statistical comparisons using non-parametric tests were made between fruit/vegetable intake, TLC, albumin and histology at presentation. Comparisons were also made between nutritional status at presentation and clinical outcome at two years. Results: 48 lesions were graded histologically: mild dysplasia (n=4), moderate (n=23), severe (n=21). Using TLC, 49% patients (n=22) were assessed to be well nourished and 51% malnourished (n=26). Albumin levels were normal for 87.5% patients (n=42) and low for 12.5% patients (n=6). 56.3% patients consumed <3 pieces of fruit/vegetable daily and 43.7% ≥3. Recurrence occurred in 48% patients (n=23). There was no significant relationship (p>0.05) between objective measures of nutritional status (albumin and TLC) or reported fruit/vegetable consumption and histological grade of dysplasia at presentation. Equally, there was no relationship between subjective or objective nutritional markers at presentation and recurrence. Conclusions: Clinical outcome at two years post laser surgery and histological grade of oral dysplasia at diagnosis is unaffected by reported fruit and vegetable intake, serum albumin and TLC at presentation.
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| Seq #226 - Nutrition Posters 3:30 PM-4:45 PM, Friday, March 23, 2007 Ernest N. Morial Convention Center Exhibit Hall I2-J | ||
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