Objectives: This research was conducted to evaluate the clinical effectiveness of an experimental nighttime whitening dentifrice versus a marketed power brush with stain removal evidence as the study control. Methods: A total of 30 generally healthy adults with visible extrinsic facial stain on 6 anterior teeth were randomly assigned to one of two regimens. The experimental group received a manual soft brush, a regular anticavity toothpaste (Crest® Cavity Protection) for the AM, and an experimental whitening dentifrice for the PM. The control group received a power toothbrush (Sonicare® Advance 4100) and the regular dentifrice for AM and PM. Subjects were instructed to brush twice daily for two minutes using the assigned regimen over a 14-day period. Stain area and intensity were measured using a standard index (Modified Lobene) at baseline, and after 7 & 14 days treatment. Results: Mean (SD) age was 47.9 (13.12) years, and all subjects completed the 14-day study. The population presented with appreciable stain at baseline, with composite stain mean (SD) of 2.71 (0.554) and 2.76 (0.924) in the experimental and control groups, respectively. Both groups exhibited significant (p < 0.0001) stain reduction at Week 1. There was incremental stain removal from Week 1 to Week 2. At the end-of-treatment, median composite stain was 85% removed in the experimental group and 89% in the control. Groups did not differ significantly (p = 0.37) on Week 2 composite stain. Both regimens were well-tolerated. Conclusion: Use of the daytime/nighttime dentifrice combination removed appreciable extrinsic stain, similar in magnitude to a power toothbrush plus regular dentifrice.

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