Objectives: The popularity of direct-to-consumer whitening systems has spurred numerous introductions into that marketplace. This clinical study evaluated tooth whitening of a new hydrogen peroxide-containing tab strip relative to a marketed strip control. Methods: A total of 60 healthy adults were randomized to hydrogen peroxide tab strips (Oral-B® Rembrandt Whitening Strips) or 10% hydrogen peroxide whitening strips (Crest® Whitestrips® Premium). Participants were supplied with the manufacturer's usage instructions, which specified 30 minutes wear time per application, QD for 5-days for the tab strips, and BID for 7-days for the control. Efficacy was measured objectively as L*a*b* color change using digital images of the maxillary anterior teeth at Baseline, Day 6, and Day 8. Results: Subjects ranged in age from 18 to 60. Adjusting for baseline tooth color and age, Day 6 adjusted means (SE) for Db* were –0.87 (0.12) for the experimental group compared to –1.66 (0.12) for the control. At respective ends-of-treatment, adjusted means (SE) for Db* were –0.87 (0.12) for the tab strips compared to –1.74 (0.12) for the whitening strip control. For DL*, end-of-treatment, adjusted means (SE) were 0.71 (0.13) for the tab strip compared to 1.84 (0.12) for the control. Groups differed significantly (p < 0.001) head-to-head at Day 6 and at end-of-treatment favoring the positive control for all color parameters. Both products were well tolerated. Conclusion: Use of the 10% hydrogen peroxide positive control provided superior whitening versus a new hydrogen peroxide whitening tab strip.

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