Objective: The purpose of this in vivo investigation is to compare the accuracy of two different electronic devices to diagnose caries. The first one using a laser technology (DIAGNOdent, KaVo, Biberach, Germany) and the second one using a LED technology (D-Carie, Neks™ Technologies, Quebec, Canada). Methods: 119 points were selected on 39 posterior teeth of patients who were scheduled for extraction. Points were probed with DIAGNOdent and D-Carie according to manufacturers' instructions. After extraction, teeth were cut along the selected points for histological evaluation under stereoscopic microscope. Results: 73.9% of the points were correctly diagnosed with D-Carie while DIAGNOdent diagnosed correctly 56.3% of the points. Sensitivity was 90.7% for D-Carie compared to 92.6% for DIAGNOdent while specificity was 60.0% for D-Carie compared to 26.2% for DIAGNOdent. Conclusion: On most aspects evaluated, D-Carie outperformed DIAGNOdent on both enamel and dentine caries detection. However, when evaluated individually and when compared to DIAGNOdent, D-Carie seems to be more efficient on enamel caries detection while the DIAGNOdent, when evaluated individually, seems to be more efficient on dentine caries detection. (Supported by Neks™ Technologies, Quebec, Canada)

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