| 1276 Topical Application of Statin Affects the Bone Healing around Implants | ||
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Y. MORIYAMA1, Y. AYUKAWA2, and K. KOYANO2, 1Kyushu University, Faculty of Dental Science, Fukuoka, Japan, 2Kyushu University, Fukuoka, Japan Objectives: HMG-CoA reductase inhibitors ("statin"), which inhibit a key enzyme in the mevalonate pathway, are widely used for the treatment of hyperlipidemia. Recent studies demonstrate that statins stimulate BMP-2 expression in osteoblasts, suggesting an anabolic effect of statins on the bone enhancement.The aim of the present study was to evaluate if the topical application of statin enhances the osteogenesis around the titanium implant, using a rat model. Methods: Commercially-pure titanium rods were inserted in both tibiae of Wistar rats. Ten-week-old female Wistar rats were divided into 5 groups with 9 rats for each groups: (1) passive control (implant only); (2) active control (implant with 0µg fluvastatin-containing propylene glycol alginate (PGA)); (3) low-dose fluvastatin (implant with 3µg fluvastatin-containing PGA) treated; (4) medium-dose fluvastatin (implant with 15µg fluvastatin-containing PGA) treated; and (5) high-dose fluvastatin (implant with 75µg fluvastatin-containing PGA) treated. The animals were sacrificed on first and second weeks of observation. Peri-implant bone formation was assessed using both histomorphometric procedures by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD). Mechanical compression test was also done to evaluate implant fixation strength. Statistical differences among groups were determined by ANOVA and P<0.05 was considered significant. Results: At week 1, there was no significant difference in BIC values among the groups however, BVD was significantly higher in 75µg group than in passive control group. At week 2, BIC was significantly higher in all fluvastatin treatment groups than in passive control group. Peri-implant BMD was also significantly increased in 75µg group in comparison with control groups. The mechanical pushout results showed a significant increase in 75µg group compared with control groups at both 1 and 2 weeks. Conclusions: Our histomorphometrical and mechanical evaluations revealed the positive effect of topically-applied fluvastatin on the bone around the implant. | ||
| Seq #109 - Diagnostics & Drugs 3:30 PM-4:30 PM, Thursday, 29 June 2006 Brisbane Convention & Exhibition Centre Exhibit Hall 1 | ||
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