| 1296 The Effect of Sensory Denervation on Orthodontic Tooth Movement | ||
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J. DAVILA, J.R. MILLER, P. VAYDA, and J. HODGES, University of Minnesota, Minneapolis, USA OBJECTIVE: Recent studies have suggested that peripheral nerve fibers participate in the control and development of the inflammatory process. The purpose of this study was to evaluate the effect of capsaicin-induced sensory denervation on the rate of orthodontic tooth movement (OTM) in the rat. METHODS: Twelve timed pregnant Sprague-Dawley rats were equally randomized into the capsaicin group and the vehicle group. Pups from their respective mothers received treatment with capsaicin or vehicle on the second day of life. At 12 weeks of age, a mesial tipping force was applied to the maxillary first molar by using 3 mm closed-coil spring activated from a bonded molar cleat to the maxillary incisors; this appliance was designed to deliver a 50-gram constant tipping force. Diastema measurements between the first and second molars were made at two and four weeks after appliance placement. Measurements were made indirectly from stone models using the MTI 3CCD camera and Optimas software. Two-way repeated-measures ANOVA was used to analyze the differences between groups. RESULTS: No significant differences were found in the amount of tooth movement between capsaicin-treated rats and controls at the collected time points (p>0.05). Similarly, the magnitude of change of tooth movement from two to four weeks did not differ between the two treatment groups (p>0.05). An increase in average diastema size was observed between two weeks and four weeks after appliance activation in both treatment groups (p<0.0001). CONCLUSION: These results suggest that neonatal capsaicin desensitization in the rat does not produce a significant effect on the rate of orthodontic tooth movement after the application of a 50-gram tipping force to the maxillary first molar. This may be due in part to the development of compensatory mechanisms in the chronically desensitized rat. Further studies are necessary to determine the reproducibility and characteristics of this treatment. | ||
| Seq #143 - Factors That Respond to or Influence Orthodontic Tooth Movement 2:00 PM-4:00 PM, Thursday, 10 March 2005 Baltimore Convention Center Exhibit Hall E-F | ||
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