Objective: A clinical study was conducted to evaluate breath malodor reduction following single and cumulative use of a triclosan-containing marketed dentifrice (blend-a-med Complete Night). Methods: The study was a three-period, cross-over study, with 2 washout periods. 29 healthy adult volunteers were acclimated for 7 days with standard toothpaste. After, subjects were randomized to three brushing regiments for each period: tooth brushing with Complete Night toothpaste, tooth brushing and tongue brushing with Complete Night, and tooth brushing with Crest® Cavity Protection toothpaste as a control. The production of volatile sulfur compounds was monitored at baseline, and again after 3, 24 & 27 hours. A questionnaire was completed after 24 & 27 hours to assess first-person perception of malodor. Results: Mean (SD) age was 40.2 (10.9) years. Relative to control, both triclosan groups experienced significant (p < 0.05) malodor reduction at 3 and 27 hours. In addition, the triclosan group with tongue brushing regimen showed significant (p < 0.05) malodor reduction versus the control at 24 hours and the no-tongue brushing group at 27 hours. Subjects using the triclosan dentifrice reported significantly (p < 0.05) higher improvement in breath compared to the control. Tongue brushing resulted in a significant (p < 0.05) improvement in the perception of tongue cleanliness. All treatments were well tolerated. There were no adverse events reported during the study. Conclusion: Use of the triclosan-containing toothpaste resulted in significant reduction in VSCs after a single dosing and with cumulative use, tongue brushing improved reduction of VSCs, and both day-time and overnight results were first-person noticeable.

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