Objective: While most peroxide-containing tooth whitening systems use various devices to deliver peroxide to the tooth surface, some are barrier-free. This clinical trial was conducted to evaluate the clinical effectiveness of a barrier-free paint-on system relative to a marketed barrier control. Methods: A total of 40 healthy adults were randomized to Colgate® Simply White™ Night, a 8.7% hydrogen peroxide, barrier-free, paint-on liquid, or Crest® Whitestrips® Premium, a 10% hydrogen peroxide gel on a whitening strip. Following the manufacturer's instructions, the paint-on was used overnight for 14 days, while the strip was applied twice daily for 7 days. All usage was unsupervised. Efficacy was measured as L*a*b* color change using digital images of the anterior dentition. Results: Adjusting for baseline and age, the end-of-treatment estimated means (SE) for Δb* (yellowness) were –0.37 (0.09) for the paint-on group (Day 15) compared to –2.05 (0.09) for the strip group (Day 8). Response similarly favored the strips for ΔL* and Δa* color change. Between-group comparisons showed highly significant (p < 0.0001) greater color improvement for the strip group for all of the individual parameters (Δb*, ΔL*, Δa*), as well as overall color improvement (ΔW*). Oral irritation was the most common adverse event overall, reported by 25% and 15% of subjects in the paint-on and strip groups, respectively. While there were no reports in the paint-on group, 6 subjects in the strip group reported transient tooth sensitivity. No subjects discontinued treatment early due to an adverse event. Conclusion: Use of the 10% whitening strip barrier system for 7 days resulted in more than five-fold superior whitening compared to 14 nights use of a barrier-free, 8.7% hydrogen peroxide paint-on liquid.

Back to the Dental Materials: IV - Clinical Trials Program
Back to the IADR/AADR/CADR 83rd General Session (March 9-12, 2005)

Top Level Search