| 1291 Effects of Celebrex on Root Resorption in the Rat Model | ||
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J. JEROME1, T. BRUNSON2, H. MOON3, and M. ZEICHNER-DAVID3, 1University of Southern California, School of Dentistry, Culver City, USA, 2University of Southern California, Santa Monica, USA, 3University of Southern California, Los Angeles, USA Tooth movement results from alveolar bone resorption/deposition following application of orthodontic forces. Using an experimental rat model we previously demonstrated that strong forces result in inflammatory root resorption concomitant to tooth movement and administration of COX1 inhibitors offered some protection. Objective: to determine if COX2 inhibitors are more effective in protecting from root resorption. Methods: 7-week-old Wistar female rats were used. The USC Animal Ethics Review Board approved animal procedures. Rats were anesthetized by intraperitoneal injection of Phenobarbital (0.15 mg/gm of body weight), a force of 80 grams was applied to maxillary left first molars using Nickel Titanium closed coil springs attached to the cervical area of the incisors with 0.010 stainless-steel ligature wire. Six animals received dosages of 40 mg of Celebrex per kg of body weight daily (administered in their drinking water) and six others received no drug serving as controls. Rats were maintained on a soft diet and sacrificed 14 days after initial placement of force. The right (control) and left maxillae (experimental) were dissected, fixed, embedded in paraffin, sectioned, Mallory stained and analyzed by light microscopy. Areas of resorption (lacunaes) were quantitated. Results: No difference in the distance of tooth movement (0.4 mm/2 weeks) was seen in both groups. Although the rats receiving the Celebrex showed a slightly lower number of lacunaes (Mean = 4.2) compared to the control group (mean = 4.4). A t-test indicated these differences were not statistically significant. Conclusions: Administration of Celebrex during the application of orthodontic forces does not interfere with tooth movement but does not offer significant protection against resorption. COX1 inhibitors appear to offer better protection, although higher doses of the COX2 inhibitor should be tested. This study was supported by NIH/NIDCR grant DE15148. | ||
| Seq #143 - Factors That Respond to or Influence Orthodontic Tooth Movement 2:00 PM-4:00 PM, Thursday, 10 March 2005 Baltimore Convention Center Exhibit Hall E-F | ||
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