Objective: Clinical research was conducted to compare the effectiveness of two dual-phase whitening dentifrices. Methods: Two clinical trials were conducted at different centers under the direction of different investigators, in order to compare the clinical response seen with dual phase whitening dentifrices. Subjects were randomized to Colgate® Simply White® Advanced Whitening Toothpaste, a dual phase dentifrice with 1% hydrogen peroxide and manganese gluconate as an activator, or Crest® Vivid White™, a dual phase dentifrice without peroxide or manganese gluconate. Subjects were provided the manufacturers' instructions for use. In each trial, whitening was measured objectively on the maxillary teeth via digital image analysis using well-established and standard methods for L*a*b* color change. A meta-analysis was conducted using the pooled raw data from the two clinical trials. Results: A total of 54 healthy adults were randomized to peroxide or no-peroxide dentifrices. After 2 weeks, the adjusted mean (SE) for Δb* (yellowness) was –0.13 (0.078) for the peroxide group, and –0.20 (0.075) for the no-peroxide group. Only the no-peroxide group differed significantly (p = 0.011) from baseline. Results were generally similar for ΔL*, with adjusted means (SE) of 0.04 (0.094) and 0.14 (0.090) in the peroxide and no-peroxide groups, respectively. While the no-peroxide group showed directionally better whitening, groups did not differ significantly. Both dentifrices were well tolerated over the 14-day treatment period. Conclusion: In this meta-analysis of two dual phase whitening dentifrices, only the whitening dentifrice without peroxide showed a significant reduction in yellowness after 14 days use.

Back to the Dental Materials: IV - Clinical Trials Program
Back to the IADR/AADR/CADR 83rd General Session (March 9-12, 2005)

Top Level Search