Objective: To investigate the efficacay of a Bioerodible Fluoridated Resin(BFR) on inhibition of enamel demineralization. Methods: Eighteen permanent posterior teeth were sectioned mesiodistally to obtain 36 caries-free enamel surfaces. Each sample was prepared by painting an acid-protective varnish, excluding a 1mm x 6mm window on either the buccal or lingual surface. The windows of natural exposed enamel were randomly divided into three separate groups(n=12). The first group received an application of a 5%NaF varnish. Group two had a BFR applied to the window. The final group was left untreated and acted as a control. The samples were then exposed to an artificial caries solution, which simulated a caries challenge. The teeth were challenged for approximately 17 days, until it was determined that a significant artificial lesion had been created on the controls. The samples were brushed for an average of one minute daily. Following the acid challenge, the teeth were sectioned longitudinally to obtain 100µm sections. Sections were then photographed under polarized light. Quantitatively the areas of the lesions were measured by utilizing a computerized imaging system. Finally, a comparison was made between mean lesion sizes of the sample groups in order to determine their respective efficacy of enamel demineralization inhibition. Results: The mean area(µm)² of the artificial lesions (±S.D.) were: BFR-3785±1794, Flouride varnish-7362±2853, and Control-11,398±4238. Conclusions: An analysis of variance(ANOVA)test was performed and identified a significant variance(p<0.001). Tukey's multiple comparison test demonstrated that BFR had significantly less enamel demineralization than the flouride varnish and control groups(p<0.05). The fluoride varnish group demonstrated significantly less enamel demineralization than the control group(p<0.05). This research was supported, in part, by DMG.

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