| 1240 Genetic signature of oral submucous fibrosis by laser capture microdissection | ||
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Y.-F. HUANG, University of Connecticut Health Center, Center for Molecular Medicine, Farmington, USA, H.-W. YANG, Chung Shan Medical University, College of Oral Medicine, Taichung, Taiwan, C. ABREU, University of Connecticut, General Clinical Research Center, Farmington, USA, and M.F. HANSEN, University of Connecticut, Center for Molecular Medicine, Farmington, USA Objectives: Oral submucous fibrosis has been closely associated with the development of oral squamous cell carcinoma. The disease is prevalent in South Asia, including India, south China and Taiwan. Oral submucous fibrosis is a premalignant lesion with little morphological or cytological abnormality when observed under light microscopy. It is estimated 10-30 % of these oral submucous fibrosis patients develop oral cancers in the lifetime. As a result of habitual chewing of betel quids, the most prevalent location to develop oral submucous fibrosis is on buccal mucosa, rendering this location as the most common oral cancer site in the Asian population. Methods: we applied laser capture microdissection to obtain RNA from lesional epithelium for cDNA microarray analysis to identify possible candidate genes that were differentially regulated between normal buccal mucosa and lesional oral submucous fibrosis tissues. Results: We found that there were 109 genes up-regulated and 169 genes down-regulated in oral submucous fibrosis relative to the normal buccal mucosa. Conclusions: these gene candidates may provide information on the development of oral submucous fibrosis. Further investigations may discover the roles of these candidate genes in the malignant transformation of oral submucous fibrosis. | ||
| Seq #137 - Cancer Discoveries 2:00 PM-4:00 PM, Thursday, 10 March 2005 Baltimore Convention Center Exhibit Hall E-F | ||
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