Seq #5 Wednesday, 10 March 2004
2:00 PM-4:00 PM Hawaii Convention Center 317-A, Symposium - Group/Division Sponsored
Salivary Gland Regeneration: Advances Toward Therapeutic Strategies

Sponsored by: Oral Medicine & Pathology, Salivary Research
Description: The field of regenerative medicine has significant implications for the future of clinical dentistry. The regeneration of salivary glands as a therapeutic option for clinicians in cases where pathological gland destruction, surgical removal, or salivary hypofunction occurs is a promising future treatment goal. Understanding the fundamental biological processes of migration, proliferation, differentiation, and apoptosis during gland morphogenesis, and in adult and degenerating glands is critical to potentially regenerating glandular tissue. Appropriate animal models are essential to investigate regenerative therapy and to translate the basic sciences to the clinical setting. Defining the role of multiple cell types in gland pathology, including acinar and ductal cells, as well as mesenchymal cells, nerves, and blood vessels will provide a rationale for orchestrating gland regeneration and restoring salivary function. The speakers will: 1) present state-of-the-art confocal live cell imaging of salivary cell migration during gland development which has implications for cell migration during gland regeneration, 2) define the role of Akt and p53 signaling in apoptosis since the suppression of apoptosis may enhance regeneration in cases of radiation damage and Sjogrens syndrome, 3) describe radiation-induced pathology in both the salivary and endothelial cells of the gland, and describe advances in potential protective treatments with implications for regeneration, 4) utilize a model of gland regeneration after duct ligation-induced degeneration, implicating inflammation in loss of function and a potential role for nerves in regeneration, 5) define the genetic profile of gland pathology in mouse models of Sjogrens syndrome, delineate the role of IFNg signaling in salivary cell proliferation, and modulate muscarinic receptor activity to regenerate functional salivary glands. The symposium will showcase young investigators who are making significant contributions to our understanding of salivary gland biology that provide the foundation for regenerating salivary glands, advancing the field toward future therapeutic strategies
Chairperson: M. HOFFMAN
 
  2:00 PM Chair's Opening Remarks
0005  2:10 PM Cell dynamics and interactions in salivary gland morphogenesis
M. LARSEN, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
  2:25 PM Discussion
  2:30 PM New insights to salivary acinar apoptosis provided by Akt transgenic mice
K.H. LIMESAND, University of Colorado, Denver, USA
  2:45 PM Discussion
  2:50 PM Salivary secretion during inflammation and following recovery
G.H. CARPENTER, GKT Dental Institute, London, United Kingdom
  3:05 PM Discussion
  3:10 PM Approaches to prevent damage and regenerate functional salivary glands after irradiation
A. COTRIM, NIDCR, bethesda, MD, USA
  3:25 PM Discussion
  3:30 PM Identification of non-immune mechanisms in the salivary gland pathology of a mouse model of Sjogren's syndrome, and a novel strategy for functional regeneration
S. CHA, University of Florida, Gainesville, USA
  3:45 PM Discussion

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