| Seq #261 | Friday, 12 March 2004 | |||||||||||||||||||
| 12:30 PM-2:30 PM Hawaii Convention Center 316-A, Symposium - Group/Division Sponsored | ||||||||||||||||||||
| Saliva-/Oral-fluid-based Diagnostic Markers of Disease | ||||||||||||||||||||
Sponsored by: Diagnostic Systems, Oral Medicine & Pathology, Salivary Research | ||||||||||||||||||||
| Description: Remarkable technological advances are revolutionizing the discipline of saliva/oral fluid-based diagnostics. Use of saliva as a diagnostic aid is a translational research success story. Saliva is used to diagnose & monitor systemic health & disease states, predict progression, detect exposure to environmental, infectious and biological substances and detect microbial biomarkers. Utility of HER-2/neu, for diagnosis and monitoring of women with breast cancer will be discussed. Strong breast cancer/salivary marker relationship may have substantial impact on this disease if an inexpensive saliva test can reduce affordability and accessibility barriers to early diagnosis. Novel approaches to harness the potential of saliva for disease diagnostics will be presented using oral cancer as a model. Diagnostic biomarkers are integrated into the Oral Fluid MEMS/NEMS Chip for ultrasensitive and specific salivary detection of proteins. This "lab on a chip" will be presented as a probe which offers real-time, painless, cost-effective disease screening. Oral samples, including saliva, gingival crevicular fluid, swabs and mucosal transudates can be used to detect a variety of pathogens and/or antibodies to them. A device to permit rapid, multiplexed analysis of pathogens and antibodies will be described. A sample is distributed into several conduits and antigen, antibody and nucleic acid detection are carried out using up-converting phosphor technology. This format permits use of cassettes for different categories of pathogens, allowing the creation of a suite of biomarkers. Patterns of oral microbiota are associated with systemic diseases such as arthritis, diabetes and CVD. Identification of microbial molecular signature patterns and characterization of interactions are essential for understanding the oral microbial community. Symposium will close with presentation of innovative DNA microarray-based technology for rapid, unambiguous detection of oral microbial biomarkers. This symposium is supported by Orasure Tech., Inc., Comprehensive Nursing Services, & the Procter & Gamble Co | ||||||||||||||||||||
| Chairperson: L. CARTER | ||||||||||||||||||||
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Back to the IADR/AADR/CADR 82nd General Session (March 10-13, 2004)