Seq #259 Friday, 12 March 2004

12:30 PM-2:30 PM Hawaii Convention Center 317-B, Symposium - Group/Division Sponsored
Neural Control of Mastication

Sponsored by: Neuroscience / TMJ
Description: Oral-motor behaviors play an essential role during feeding. Oral-motor dysfunction can occur across one’s life span and result in devastating outcomes. Pediatric oral-motor disorders include difficulties coordinating sucking, swallowing and breathing, ultimately jeopardizing an infant’s survival and growth. In adults, tardive dyskinesia, chronic myofacial pain syndromes, and brainstem degeneration associated with chronic neurological disorders result in oral-motor dysfunction, malnutrition and wasting. The etiology of these and other oral-motor dysfunctions are not well understood, based in part from a poor understanding of the structure and function of neural circuits that underlie these behaviors. Recent biomedical technologies have allowed us to develop a better understanding of the complex neural systems regulating oral-motor behaviors, and the etiology and pathogenesis of oral-motor dysfunction. Faculty in this symposium will discuss current knowledge regarding the neural control of mastication, from molecular, cellular, systems, and human behavioral perspectives. The first talk will address the development of trigeminal neurons associated with mastication. Data presented will illustrate cell and molecular neuronal changes that occur during the transition from suckling to chewing behaviors, with a focus on the impact of tooth eruption on the transition between sucking and chewing. The second talk will focus on the rhythmical nature of masticatory behaviors and discuss cellular mechanisms that account for the rhythmical bursting observed in neurons comprising masticatory circuits. The third talk will focus on the role of somatosensory receptors in modulating masticatory circuits. This talk will also address the role of neuropeptides utilized by somatosensory neurons within sensorimotor circuits that underlie mastication, with a focus on pain modulation of central circuits. The fourth talk will present recent data regarding the role of reflexes in the execution of human mastication and will discuss a paradigm to evaluate and quantify human masticatory behavior
Chairperson: J. TURMAN, Jr.
 
  12:30 PM Chair's Opening Remarks
2608  12:35 PM DEVELOPMENTAL INTERACTIONS BETWEEN TRIGEMINAL NEURONS AND CRANIOFACIAL STRUCTURES
J. TURMAN, Jr., University of Southern California, Los Angeles, USA
  1:00 PM CELLULAR MECHANISMS UNDERLYING RHYTHMICAL BURSTING IN BRAINSTEM ORAL-MOTOR CIRCUITS
S. CHANDLER, University of California - Los Angeles, USA
  1:25 PM THE ROLE OF SOMATOSENSORY RECEPTORS IN MASTICATION
D. DESSEM, University of Maryland Baltimore Dental School, USA
  1:50 PM REFLEX CONTROL OF HUMAN MASTICATION
K. TURKER, University of Adelaide, AUS-S. Adelaide, Australia
  2:15 PM Panel Discussion

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