Seq #394 Saturday, 13 March 2004
12:30 PM-2:30 PM Hawaii Convention Center 316-B, Symposium - Group/Division Sponsored
Gene Expression and the Genomics of Pain and Analgesic Drug Actions

Sponsored by: Neuroscience / TMJ, Pharmacology, Therapeutics, & Toxicology
Description: Gene Expression and the Genomics of Pain and Analgesic Drug Actions Despite dramatic advances in the neurosciences and pharmacology, analgesic therapy for the past century has been largely limited to local anesthetics, opioids and aspirin-like drugs (i.e. NSAIDs) with the unique limitations of each class. The number of potential targets for analgesia, however, has grown from the traditional few dozen neurotransmitters and inflammatory mediators that have been studied for decades to include an estimated 10 million single nucleotide polymorphisms (SNPs) in humans. If even only a small percentage of this variability contributes to the inflammatory/pain cascade, neural immune interactions and the development of sensitization over time, this would readily explain the apparent differences in pain mechanisms across various diseases and disorders. Current clinical analgesic trials are based on group responses of relatively homogeneous patient samples in standardized clinical models and neither account for this wide molecular-genetic diversity nor provide a basis for extrapolating to heterogeneous patient populations and the use of drugs across varying diseases. This symposium will review the genetic influences on the perception of acute and chronic pain, the development of sensitization and the pharmacogenomics of analgesic drug actions with an emphasis on data from animal and clinical models relevant to dentistry
Chairpersons: R. DIONNE and K. HARGREAVES
 
  12:30 PM Chair's Opening Remarks
3918  12:40 PM Role of COX Expression on the Development of Pain and Actions of Selective COX-2 Inhibitors
A.A. KHAN, University of Texas - San Antonio / Health Science Ctr, USA
  1:05 PM Genetic Influences of Single Nucleotide Polymorphisms on Pain Perception
R. DIONNE, Natl Institute of Dental & Craniofacial Rsch NIDCR, Bethesda, MD, USA
  1:30 PM Genomic Influences on Pain Sensitivity and Temporomandibular Disorders
W. MAIXNER, University of North Carolina, Chapel Hill, USA
  1:55 PM Single Gene Polymorphisn Significantly Affects mu-Opoid Mediated Pain Suppression
C. STOHLER, University of Maryland, Baltimore, USA
  2:20 PM Discussion

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