| 1797 Biphasic calcium phosphate scaffolds via polymeric sponge method combining gel-casting | ||
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Y.-U. KIM1, D.-Y. LEE1, Y.-K. LEE1, K.-M. KIM2, K.-N. KIM1, S.-H. CHOI3, C.-K. KIM3, and R.Z. LEGEROS4, 1Medical Science and Engineering Research Center, Yonsei University College of Dentistry, Seoul, South Korea, 2Dept & Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, South Korea, 3Dept. of Periodontics, Yonsei University College of Dentistry, Seoul, South Korea, 4New York University College of Dentistry(NYUCD), USA Objectives: Polymeric sponge method combining gel-casting is introduced in this study to prepare biphasic calcium phosphate(BCP) scaffolds, which provides a better control over the microstructures and enhances their mechanical properties. Methods: HA, b-TCP, functional acrylamide, methylenebisacrylamide, dispersant and silicon based defoamer mixed with DI water. The slurry prepared was deagglomerated by ball milling for 24h and deaired under vacuum until no further release of air bubbles from the sample. Catalyst and initiator were added to the slurry to polymerize the monomers. Polymeric sponges were completely immersed into the slurry under vacuum to force the BCP powders to migrate into the pores of the sponges, and then dried in air for 24h. The samples were heated at a rate 1 degree of Celsius/min to 600 degree of Celsius for 1h to burn out the polymeric sponges. The samples were sintered at a rate 3 degree of Celsius/min to 1300 degree of Celsius for a dwell time of 4h. The sintered scaffolds were measured compressive strength with UTM at a crosshead speed of 1mm/min. Dissolution properties were determined from release of calcium ions with time onto acidic buffer. Statistical analysis ANOVA Tukey's Studentized Range (HSD) test, and T test were used. Results: The scaffolds prepared have an open and interconnected porous structure. The compressive strength of scaffolds by combined polymeric sponge and gel-casting method were increased compare to polymeric sponge methods(p<0.05). Dissolution properties depended on HA/ b-TCP ratio of the BCP. One of the principal way of controlling the bioactivity of BCP is by manipulating the HA/b-TCP ratios. Conclusion: BCP scaffolds with desired interconnected pore and improved mechanical properties can be prepared by combining polymeric sponge and gel-casting methods. This work was supported by grant No. R13-2003-13 from the Medical Science and Engineering Research Program of the Korea Science & Engineering Foundation. | ||
| Seq #203 - Ceramics and Cements: Clinical and Biological Evaluation 10:15 AM-11:30 AM, Friday, 12 March 2004 Hawaii Convention Center Exhibit Hall 1-2 | ||
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