Objective: The objective of this research was to quantitatively evaluate the anti-microbial efficacy of commercial denture adhesive formulations. Methods: A kill kinetic assay was used to evaluate the anti-microbial efficacies of commercial denture adhesive formulations. A 24-hour-old culture of Streptococcus mutans (plaque-bacteria) was exposed to the denture adhesive formulations and an aliquot of the streptococcal culture was diluted into a neutralizing broth. The dilutions were subsequently plated onto Tryptic Soy Agar and incubated in a CO₂ atmosphere for a period of 8 hours. The viable organisms on the agar plates were enumerated and the log of Colony-Forming Units per ml were calculated. Exact Wilcoxon Rank Sum test was used for treatment comparison. Results: Fixodent denture adhesive formulations showed the best anti-microbial efficacy with significantly (p<0.05) less Streptococcus mutans relative to negative control. The mean difference of the Streptococcus mutans between the negative control and Fixodent denture adhesive formulations were greater than 2 log CFU. Conclusions: This research found that Fixodent denture adhesive formulations provide significant anti-microbial efficacy and may help improve the oral hygiene of denture patients by reducing plaque-bacteria.

Back to the Prosthodontics Research Program
Back to the IADR/AADR/CADR 82nd General Session (March 10-13, 2004)

Top Level Search