Objective: This research compared the clinical response of two different peroxide-containing gel formulations delivered using self-applied whitening strips. Methods: A randomized, double-blind clinical trial was conducted to compare a 1-week 10% hydrogen peroxide thin bleaching gel (Crest® Whitestrips® Premium to a marketed 2-week 6% hydrogen peroxide strip control (Crest® Whitestrips®). The maxillary arch was treated twice daily for 30 minutes. Efficacy (L*a*b* color change) was measured objectively by digital image analysis after 1 & 2 weeks. Results: A total of 40 adults ranging from 19-48 years of age participated in the study. Both treatments were effective in whitening teeth, as evidenced by a statistically significant improvement from baseline (p < 0.001) beginning at 1-week. At that time, the adjusted mean Db* (SE) for the 10% strip was –2.42 (0.147) compared to –1.91 (0.143) for the marketed control, with the treatments differing significantly (p < 0.05). At Week 2, the adjusted mean Db* (SE) for the 10% strip was –3.31 (0.182) compared to –2.49 (0.167) for the marketed control. After 2-weeks, treatments differed significantly (p < 0.02) for Db*, DL*, DE* and DW*. Comparing 2-weeks of the 6% control strip and 1-week of the 10% strip, the mean Db* treatment difference was –0.07 (90% confidence interval from –0.44 to +0.31). Both treatments were generally well tolerated, with mild and transient tooth sensitivity or oral irritation representing the most common adverse events. Conclusion: Vital bleaching with 10% hydrogen peroxide strips for 1-week was as effective as 6% hydrogen peroxide strips for 2-weeks.

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