| 3500 Effect of plasma surface modification on machined titanium surfaces | ||
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C.-H. CHEN1, K.-L. OU1, S.-Y. LEE2, and C.-T. LIN3, 1Taipei Medical University, Taiwan, 2Taipei Medical University, Wang Fang Hospital, Taiwan, 3Taipei Medical University, College of Oral Science, Taiwan Objectives: Since the first dental implant was placed, implantologists have been attempting to understand the implant/bone integration mechanisms. By medication of the surface morphology, a mechanical interlock between the implant and the surrounding bone bed could be achieved. But closer examination of the interface demonstrated that fibrous connective tissue intervened between the material and the bone. In order to improve implant/bone integration, it is desirable to control interfacial reactions such that nonspecific adsorption of proteins is minimized and tissue-healing phenomena can be controlled. The purpose of this study was to develop a new method to functionalize titanium surfaces by plasma treatment so that tissue can be healing as soon as possible. Methods: Plasma treatment was performed to cleaning surface and polymerization to linking a functional group on plasma-treated titanium surface. The covalent immobilization of bioactive organic molecules and in vitro bioactivity were evaluated by x-ray diffraction (XRD), atomic force spectroscopy (AFM), x-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and MTT assay. Results: Argon plasma removes all adsorbed contaminates and impurities. Our results reveal that plasma-cleaned titanium surfaces provide a clean and reproducible starting condition for further plasma treatments to form well-controlled surface layers. Allylamine was ionized by the plasma treatment process, and dangling bonds acted as a medium to link albumin. Cells had spread well, and good attachment was attained on the albumin/allylamine/TiO2/Ti surface. It was revealed that attachment and growth of cells are influenced by the surface properties. The plasma treatment process plays an important role in facilitating tissue healing. This process not only provides a clean titanium surface, but also produces surface amination on plasma-treated titanium surfaces. Conclusion: Surface cleaning by ion bombardment and surface modification by chemical polymerization of plasma treatments are believed to remove contamination on titanium surfaces and hence promote tissue healing. | ||
| Seq #360 - Biomechanics/Implant Surfaces 10:15 AM-11:30 AM, Saturday, 13 March 2004 Hawaii Convention Center Exhibit Hall 1-2 | ||
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