Objective: To evaluate the efficacy of a dentifrice containing NovaMin compared to a negative control dentifrice without NovaMin as well as a positive control dentifrice containing SrCl2 in relieving dentine hypersensitivity over a period of 6 weeks. Material and Methods: The study design was randomized, double-blinded, with a positive and negative control group.Seventy- five (75) qualified volunteers took part in the study according to the inclusion and exclusion criteria. Tooth sensitivity was recorded by marking the degree of discomfort on a 10 cm long VAS when elicited by air blast and cold-water stimulus with a minimum interval of 5 minutes. A soft tissue examination of the mouth was carried out to assess any effects of the dentifrice on oral soft tissues. Changes were assessed for statistical significance using ANOVA. Results: Seventy-one subjects finished the study, the age ranges from 20 to 56 years old. The results showed that the mean values of the VAS scores resulting from the air stimulus and cold water were reduced significantly (p<0.01) in both test and positive control group after six weeks of tooth brushing. After 6 weeks use, the reduction in the test group was 22% for air and 39% for cold water and in the positive control group it was 19% for air and 22% for cold water. There was no significant difference of the mean values of the VAS scores in the negative control group without NovaMin between baseline and 6 weeks. No product related adverse events on oral soft tissue were found in this six week study. Conclusion: The results of this study showed that the test dentifrice containing NovaMin and the positive control toothpaste reduced dentine sensitivity significantly over the 6 week study. Supported by Wuhan LiBaiSheng Technology Co. Ltd., Wuhan, P.R.China and NovaMin Technology, Inc., Alachua, Florida, USA.

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