| 1237 Microvessel Volume in Normal and Dysplastic Oral Epithelium | ||
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V.P.A. OO, University of Malaya, Kuala Lumpur, Malaysia, and C.H. SIAR, University of Malaya, Kuala Lumpur, Malaysia Objectives: To assess and compare the microvessel distribution between normal and dysplastic oral epithelium. Methods: Seventy(20 mild epithelial dysplasia /ED, 20 moderate ED, 20 severe ED, 10 normal oral mucosa) cases were retrieved from the archives of the Department of Oral Pathology, Oral Medicine & Periodontology, Faculty of Dentistry, University Malaya, and Institute for Medical Research, Kuala Lumpur, Malaysia. H&E and immunohistochemical staining with three vascular markers (CD31, CD34 and CD105)were performed. The grading of ED was in accordance with WHO recommendations. Angiogenic assessment was carried out blind using an image analyser. For microvessel volume(MVV) score, the average of four areas with the highest vessel density was obtained. Results: Mean MVV score for each marker shows a positive corelation with the grading of ED. Conclusion: Current findings show that anigogenesis is upregulated in dysplastic oral epithelium compared with normal mucosa. (Study is supported by Vote F Grant F0209/2003A) | ||
| Seq #126 - Oral Cancer and Precancer: Diagnosis and Biomarkers 10:15 AM-11:30 AM, Thursday, 11 March 2004 Hawaii Convention Center Exhibit Hall 1-2 | ||
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