| 1799 The biologic effect of HA/FA-coated porous Zirconia in bone regeneration | ||
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I.-C. RHYU1, S.-Y. SHIN1, H.-W. KIM2, H.-E. KIM2, Y.-M. LEE1, and S.-B. HAN1, 1Seoul National University, College of Dentistry, South Korea, 2Seoul National University, South Korea Objectives: This study was aimed to evaluate the biologic effect of hydroxyapatite(HA)/ fluorapatite(FA) coated porous Zirconia in bone formation in the rabbit calvaria. Methods: Three kinds of HA/FA coated porous ZrO2 bodies(high porosity with large pore size; HL, high porosity with small pore size; HS, low porosity with large pore size; LL) and one kind of porous pure HA body were prepared. Eighteen male New Zealand white rabbits were divided into 5 groups(Control/HA/HL/HS/LL). Results: Two 10 mm diameter full-thickness calvaria defects were made using a trephine drill bilaterally and symmetrically and 4 kinds of graft materials were placed. No graft material was placed in the control defects. Each 9 rabbits were sacrificed at 4 and 12 weeks after surgery and undecalcified ground specimens were prepared. Microscopic examination and histomorphometric analysis in the area of the newly formed bone were conducted Conclusions: All specimens showed no adverse tissue reaction and all defects showed good healing response. At 4 weeks postsurgery, there was large new bone formation(16.2 - 24.2%) except in control.(4.30%) At 12 weeks, there was large increase of bone fill except in group LL. Porous ZrO2 scaffolds coated with HA/FA showed a good bone regeneration ability especially in a higher porosity graft material. Therefore porous ZrO2 scaffold coated with HA/FA will be used as a good bone scaffolding material in bone regeneration. | ||
| Seq #203 - Ceramics and Cements: Clinical and Biological Evaluation 10:15 AM-11:30 AM, Friday, 12 March 2004 Hawaii Convention Center Exhibit Hall 1-2 | ||
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