Objective: Present clinical trial was designed to study effect of Oxygene Gel^® Aloe enriched on healing of periodontal pockets following mechanical non-surgical therapy. Methods: Sample included 16 patients, with chronic adult periodontitis. These patients had paired teeth with pockets ≥6 mm in opposing sides of the mouth in this crossover design study. Fifty-eight teeth with pockets measuring 6-9 mm were alternately assigned to 2 treatment groups: scaling and root planing as well as application of test gel versus scaling and root planing alone. Root planing was performed at baseline for test and control teeth. The test gel was injected into pockets of test teeth at baseline, 1-week and 2-weeks intervals. One of the control teeth was extracted during the study eventually leaving 28 control teeth which were evaluated against the paired 28 test teeth. The trial extended over an 8-week period and assessments of probing pocket depth (PPD), loss of attachment (LOA), mobility, bleeding on probing (BOP) and plaque indices were made at baseline, 4th and 8th week intervals following therapy. Statistical analysis was performed using Wilcoxon Matched-Paired Signed Rank test. Results: The test gel as an adjunct to mechanical therapy significantly decreased PPD (p<0.05 – <0.001) on all 5 surfaces except on the midbuccal; reduced LOA (p<0.05 – <0.01) on the midlingual and distolingual surfaces; decreased BOP scores (p<0.05 – <0.001) on the mesial, distal and lingual sites and decreased mobility scores (p<0.05) of test teeth at the 8th week interval as compared to control group. Conclusion: Results of this study conducted on patients with teeth having deep periodontal pockets of ≥ 6 mm suggests a possible role for this gel of Chlorine dioxide and Aloe vera in the treatment of chronic adult periodontitis compared to nonsurgical treatment alone. (Study supported by Vote F, University of Malaya)

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