Objective: Compare the fluoride release and uptake by two glass ionomer (Fuji II LC, Vitremer) and a resin modified glass ionomer cements (Fuji Ortho LC) under the effects of recharge vehicles (gel, mouthrinse, dentifrice and varnish) for 21 days. Methods: Seventy five rectangular shaped samples of 15mm x 10mm x 1mm were prepared, twenty five of each type of material. Each sample was immersed in 25ml of deionized water and maintained at 37ºC. The measurements were made daily for the first 5 days and later every fifth day until the end of the study (previously stabilized with 5ml of buffer Tisab III – Orion), in mV with a fluoride selective electrode (Orion 9409) coupled to a benchtop analyzer (Orion EA920). Within each type of material five samples were fluoridated with each type of vehicle (12300ppm gel, 220ppm mouthrinse, 1500ppm dentifrice and 1000ppm varnish) at the start and every fifth day. ANOVA and Games-Howell tests were used to analyze the data. Results: All the materials presented the greatest fluoride release at the first day with a tendency to decrease. The type of material did not present any significant difference in the release and uptake effect (p>0.05). The type of vehicle used did present significant difference on the release and uptake effect of each material, specially the gel which presented the greatest values. Conclusions: The uptake effect by the vehicles made the materials to increase its fluoride release at the moment of application being the gel the one with the greatest effect.

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