| Seq #1 |
Wednesday, 25 June 2003 |
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| 2:00 PM-4:00 PM Svenska Massan G1, Symposium - Group/Division Sponsored |
| Cellular Microbiology |
| * Poster files available online |
Sponsored by: Microbiology / Immunology and Infection Control |
| Description: Bacteria that initiate infections at mucosal surfaces often engage host cells in an intricate molecular dialogue. Bacteria can exploit host cell signaling pathways in order to internalize and survive intracellularly. Host cells are capable of sensing and responding to the presence of bacteria and participate in an elaborate communication network that can modulate both innate and acquired immune responses. Thus, the outcome of this pathogen-host cross-talk provides an important contribution to the overall health status of the host. This symposium will address several aspects of the interplay between bacterial and eukaryotic cells. The adaptation of Bordetella to the respiratory tract and the tightly regulated continuum of virulence gene expression states will be discussed, along with the ability of bacteriophages to promote genetic variability in Bordetella. In the oral arena, the intrusion of host cells and tissue by periodontal pathogens will be addressed. Chemotaxis guided tissue penetration and Fusobacterium induced apoptosis will be explored, as will intracellular trafficking of P. gingivalis within endothelial cells and its relevance to systemic health. Finally the mechanism of immune cell recognition of P. gingivalis surface molecules such as LPS will be described. These talks will integrate key components of the processes and pathways by which bacteria and host cells adapt to each other, leading in some instances to a long term commensal relationship, and in others to tissue destruction and disease. This symposium is supported by New England BioLabs and 3M ESPE |
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2:00 PM | Chair's Opening Remarks |
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2:05 PM | Parasite Adaptation to Dynamic Hosts: Bordetella and their Phage
J.F. MILLER, UCLA, Los Angeles, CA, USA |
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2:45 PM | Chemotaxis Guided Tissue Penetration and Fusobacterium Induced Apoptosis
W. SHI, UCLA School of Dentistry, Los Angeles, CA, USA |
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3:05 PM | Intracellular Trafficking of P. gingivalis
A. PROGULSKE-FOX, University of Florida, Gainesville, USA |
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3:25 PM | Immune Cell Recognition of P. gingivalis LPS
R.P. DARVEAU, University of Washington, Seattle, USA |
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3:45 PM | Discussion |
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